For 3D modeling, you can get a 3D mouse such as the SpaceMouse.
Sometimes you can get the closed source Mali drivers to run on Linux, but it’s a lot of work and usually requires running an old kernel. I don’t know if you can get it to work for the Orange Pi 5 though. It’s probably not worth the effort considering the poor performance you will get running x86-64 code on ARM.
The stock software will not run in Wine. I would suggest picking hardware that’s supported by Piper.