Maybe check ProtonDB. You can usually find game specific issues and solutions. The page for Metro: Last Light Redux is here.
The Nvidia X Server Settings is quite limited but im pretty sure that it can do color correction, but i noticed that on Pop OS the app needs some extra tinkering to get all the options to show up.
Try running it from the terminal and see if any errors show up. I remember it threw some errors about keys or smth and because off that a lot of options would be missing (including color correction).
I honestly don’t realy know. The Arch wiki says that there are some differences with AMF and OpenCL but I don’t know how up to date that information is.