Is this only with Warframe? Do you use X11? If so, could it be defaulting to a lower Hz second monitor or something? I suffered with this for years until I swapped to Wayland. Just a thought.
De-Googling is something I did about 5 years ago. It took me about 6 months on and off, but I’m super happy I did. There are always other (and actually better) alternatives to their services. The only one that I struggle not to use is YouTube - the alternatives are all worse.
You may have seen this already, but on the GloriousEggroll Github it mentions not having V-sync set to “Auto”
https://github.com/GloriousEggroll/proton-ge-custom?tab=readme-ov-file#notes