I think the biggest challenge is anti-cheat. I don’t know if there is any solution instead of waiting for native release (like Dota2 and CSGO). Also, although I don’t like Microsoft GamePass, lacking the support of it means we may need to pay extra to try various games.
I think Wine/Proton works really great nowadays (well I’ve repeated it at different places). As 2023-07-28, ProtonDB shows that in the top 1000 games, 75% are rated gold or better.
When it comes to distro, I think most popular ones are good enough if they meet to conditions
(1) packages are not too out-dated
(2) Not difficult to install some non-free dependencies (like rpmfusion)
I wonder why DOTA2 was not mentioned… It has a really decent Linux support for more than a decade