I have both, a personal domain with my name and also an anonymous generic domain. I use the anonymous one for 90+% of my online stuff, and use a random unique address for every service (you can set up a wildcard in proton, so *@domain.org lands in the same inbox). I would recommend that for two reasons: if you own your anonymous domain you can move your mailprovider anytime (as opposed to using some email masking service), using unique addresses for every service enables you to easily figure out which one leaked your address if you start getting spam. Just make sure to use a generic name for the domain and dont get an exotic TLD (just get a .com .org or something). Some of the non traditional TLDs may negatively impact your spam scores, and its easy to find a .com or .org when you can literally choose any domain name you want.
Have also been using it for a while now, it’s the best alternative I tried so far. downsides are cost, closed-source, and my fear that they’re gonna take VC money in the future. So far, I can stand behind their offering tho. And the built-in feature to lower or raise results from certain pages is amazing.
The current bio model does not support PIV (Smartcard) tho, so it cant be used for PGP/SSH. They recently announced a new revision that can, but its not generally available yet.
https://www.yubico.com/blog/introducing-the-expanded-yubikey-bio-series-yubikey-bio-multi-protocol-edition-early-access/