I’d highly recommend checking out Nobara, it’s based on Fedora but optimized for gaming. In addition to supporting nVidia out of the box, it has a ton of tweaks and gaming related apps pre-installed, such as Steam and Lutris, which is a huge time saver. Should be the most out-of-the-box gamer friendly distro, outside of SteamOS I reckon.
Then let’s agree to disagree, in my experience they’ve been more of a hassle to deal with. Eg trying to fix the weird DPI/tiny cursor issue in the flatpak version of Steam was a pain, same with trying to pass custom flags to flatpak Edge. It’s just one hassle after another. I can deal with a couple of apps here and there, but I can’t imagine having the entire system depend on Flatpak as a crutch.
As for your Wine example, I’m not sure which application you’re referring to, but Wine is basically portable and doesn’t need installing, eg for Wine-GE, you just need to download and extract the tarball and set the correct WINEPREFIX/path, so you can easily have multiple versions of Wine on your system without Flatpak or anything complicated.