It looks like an issue with the premade Lutris installer/config package.

Can you try downloading the installer from GOG and install manually in Lutris via the “Install a Windows Game from an executable” (the + button on the top left) option?

There you can choose “Windows XP 32bit” as an Installer preset, this should provide the best compatibility.

The list in the GitHub is the reference as far as I know https://github.com/ValveSoftware/Proton?tab=readme-ov-file#runtime-config-options

But the NVAPI change is not listed yet.

Open Source Drivers for Nvidia Cards are still very early and very limited. The best way to go forward would most likely be to solve whatever conflict exists on your system with the proprietary drivers and then to use those. Or to get a AMD graphics card.

Skyrim and Fallout Modding are, kind of, the reason I still have a Windows installation on my PC.

Most of it works great in Linux but Tools like Nemesis or even worse Synthesis will either don’t start at all or produce walls of errors when run in Linux.

Basic Starfield modding will most likely be not an issue at all.

Kind of both in some way. New company with a few of the old people under new management.

https://www.kotaku.com.au/2020/05/the-australian-who-brought-microprose-back-from-the-dead/