I got Skyrim from GOG, and am not able to run it with Wine, I remember running Skyrim AE GOG a couple months ago, and don't what changed.
I get this running SkyrimSE.exe from terminal
```
info: Game: SkyrimSE.exe
info: DXVK: v2.2
info: Vulkan: Found vkGetInstanceProcAddr in winevulkan.dll @ 0x2d4ad3f50
info: Built-in extension providers:
info: Win32 WSI
info: OpenVR
info: OpenXR
info: OpenVR: could not open registry key, status 2
info: OpenVR: Failed to locate module
info: Enabled instance extensions:
info: VK_KHR_get_surface_capabilities2
info: VK_KHR_surface
info: VK_KHR_win32_surface
ac_compute_device_uuid's output is based on invalid pci bus info.
info: AMD Radeon Graphics:
info: Driver : AMD open-source driver 2.0.267
info: Memory Heap[0]:
info: Size: 7656 MiB
info: Flags: 0x0
info: Memory Type[1]: Property Flags = 0x6
info: Memory Type[3]: Property Flags = 0xe
info: Memory Type[5]: Property Flags = 0xc6
info: Memory Type[7]: Property Flags = 0xce
info: Memory Type[9]: Property Flags = 0x6
info: Memory Type[11]: Property Flags = 0xe
info: Memory Type[13]: Property Flags = 0xc6
info: Memory Type[15]: Property Flags = 0xce
info: Memory Heap[1]:
info: Size: 512 MiB
info: Flags: 0x3
info: Memory Type[0]: Property Flags = 0x1
info: Memory Type[2]: Property Flags = 0x7
info: Memory Type[4]: Property Flags = 0xc1
info: Memory Type[6]: Property Flags = 0xc7
info: Memory Type[8]: Property Flags = 0x1
info: Memory Type[10]: Property Flags = 0x7
info: Memory Type[12]: Property Flags = 0xc1
info: Memory Type[14]: Property Flags = 0xc7
05c0:fixme:system:QueryDisplayConfig (00000002 0000000000218548 00000000023ED9C0 000000000021854C 00000000019D3B60 0000000000000000): semi-stub
05c0:fixme:system:QueryDisplayConfig (00000002 0000000000218548 00000000023ED9C0 000000000021854C 00000000019D3B60 0000000000000000): semi-stub
05c0:fixme:system:QueryDisplayConfig (00000002 00000000002185C8 00000000023ED9C0 00000000002185CC 00000000019D3B60 0000000000000000): semi-stub
05c0:fixme:system:QueryDisplayConfig (00000002 00000000002151BC 00000000023ED9C0 0000000000215220 00000000019D3B60 0000000000000000): semi-stub
warn: D3D11DeviceFeatures: External memory features not supported
info: D3D11CoreCreateDevice: Maximum supported feature level: D3D_FEATURE_LEVEL_12_0
info: D3D11CoreCreateDevice: Using feature level D3D_FEATURE_LEVEL_11_0
info: Device properties:
info: Device : AMD Radeon Graphics
info: Driver : AMD open-source driver 2.0.267
info: Enabled device extensions:
info: VK_AMD_memory_overallocation_behavior
info: VK_AMD_shader_fragment_mask
info: VK_EXT_attachment_feedback_loop_layout
info: VK_EXT_conservative_rasterization
info: VK_EXT_custom_border_color
info: VK_EXT_depth_clip_enable
info: VK_EXT_extended_dynamic_state3
info: VK_EXT_hdr_metadata
info: VK_EXT_memory_priority
info: VK_EXT_non_seamless_cube_map
info: VK_EXT_robustness2
info: VK_EXT_shader_module_identifier
info: VK_EXT_shader_stencil_export
info: VK_EXT_transform_feedback
info: VK_EXT_vertex_attribute_divisor
info: VK_KHR_pipeline_library
info: VK_KHR_swapchain
info: Device features:
info: robustBufferAccess : 1
info: fullDrawIndexUint32 : 1
info: imageCubeArray : 1
info: independentBlend : 1
info: geometryShader : 1
info: tessellationShader : 1
info: sampleRateShading : 1
info: dualSrcBlend : 1
info: logicOp : 1
info: multiDrawIndirect : 1
info: drawIndirectFirstInstance : 1
info: depthClamp : 1
info: depthBiasClamp : 1
info: fillModeNonSolid : 1
info: depthBounds : 1
info: multiViewport : 1
info: samplerAnisotropy : 1
info: textureCompressionBC : 1
info: occlusionQueryPrecise : 1
info: pipelineStatisticsQuery : 1
info: vertexPipelineStoresAndAtomics : 1
info: fragmentStoresAndAtomics : 1
info: shaderImageGatherExtended : 1
info: shaderClipDistance : 1
info: shaderCullDistance : 1
info: shaderFloat64 : 1
info: shaderInt64 : 1
info: variableMultisampleRate : 1
info: shaderResourceResidency : 1
info: shaderResourceMinLod : 1
info: sparseBinding : 1
info: sparseResidencyBuffer : 1
info: sparseResidencyImage2D : 1
info: sparseResidencyImage3D : 1
info: sparseResidency2Samples : 0
info: sparseResidency4Samples : 0
info: sparseResidency8Samples : 0
info: sparseResidency16Samples : 0
info: sparseResidencyAliased : 1
info: Vulkan 1.1
info: shaderDrawParameters : 1
info: Vulkan 1.2
info: samplerMirrorClampToEdge : 1
info: drawIndirectCount : 1
info: samplerFilterMinmax : 1
info: hostQueryReset : 1
info: timelineSemaphore : 1
info: bufferDeviceAddress : 0
info: shaderOutputViewportIndex : 1
info: shaderOutputLayer : 1
info: vulkanMemoryModel : 1
info: Vulkan 1.3
info: robustImageAccess : 0
info: pipelineCreationCacheControl : 1
info: shaderDemoteToHelperInvocation : 1
info: shaderZeroInitializeWorkgroupMemory : 0
info: synchronization2 : 1
info: dynamicRendering : 1
info: VK_AMD_shader_fragment_mask
info: extension supported : 1
info: VK_EXT_attachment_feedback_loop_layout
info: attachmentFeedbackLoopLayout : 0
info: VK_EXT_conservative_rasterization
info: extension supported : 1
info: VK_EXT_custom_border_color
info: customBorderColors : 1
info: customBorderColorWithoutFormat : 1
info: VK_EXT_depth_clip_enable
info: depthClipEnable : 1
info: VK_EXT_extended_dynamic_state3
info: extDynamicState3AlphaToCoverageEnable : 1
info: extDynamicState3DepthClipEnable : 1
info: extDynamicState3RasterizationSamples : 1
info: extDynamicState3SampleMask : 1
info: VK_EXT_fragment_shader_interlock
info: fragmentShaderSampleInterlock : 0
info: fragmentShaderPixelInterlock : 0
info: VK_EXT_full_screen_exclusive
info: extension supported : 0
info: VK_EXT_graphics_pipeline_library
info: graphicsPipelineLibrary : 0
info: VK_EXT_memory_budget
info: extension supported : 1
info: VK_EXT_memory_priority
info: memoryPriority : 1
info: VK_EXT_non_seamless_cube_map
info: nonSeamlessCubeMap : 0
info: VK_EXT_robustness2
info: robustBufferAccess2 : 1
info: robustImageAccess2 : 1
info: nullDescriptor : 1
info: VK_EXT_shader_module_identifier
info: shaderModuleIdentifier : 1
info: VK_EXT_shader_stencil_export
info: extension supported : 1
info: VK_EXT_swapchain_colorspace
info: extension supported : 0
info: VK_EXT_hdr_metadata
info: extension supported : 1
info: VK_EXT_transform_feedback
info: transformFeedback : 1
info: geometryStreams : 1
info: VK_EXT_vertex_attribute_divisor
info: vertexAttributeInstanceRateDivisor : 1
info: vertexAttributeInstanceRateZeroDivisor : 1
info: VK_KHR_external_memory_win32
info: extension supported : 0
info: VK_KHR_external_semaphore_win32
info: extension supported : 0
info: VK_NVX_binary_import
info: extension supported : 0
info: VK_NVX_image_view_handle
info: extension supported : 0
info: Queue families:
info: Graphics : 0
info: Transfer : 2
info: Sparse : 0
info: Memory type mask for sparse resources: 0xf
warn: DXVK: No state cache file found
info: DXVK: Graphics pipeline libraries not supported
info: DXGI: VK_FORMAT_D24_UNORM_S8_UINT -> VK_FORMAT_D32_SFLOAT_S8_UINT
info: Presenter: Actual swap chain properties:
info: Format: VK_FORMAT_B8G8R8A8_UNORM
info: Color space: VK_COLOR_SPACE_SRGB_NONLINEAR_KHR
info: Present mode: VK_PRESENT_MODE_IMMEDIATE_KHR
info: Buffer size: 1920x1080
info: Image count: 3
info: Exclusive FS: 1
05c0:fixme:system:QueryDisplayConfig (00000002 0000000000217F08 00000000023F9660 0000000000217F0C 0000000002451390 0000000000000000): semi-stub
info: Setting display mode: 1920x1080@60
info: Setting display mode: 1920x1080@60
05c0:fixme:system:QueryDisplayConfig (00000002 0000000000218468 00000000023F9660 000000000021846C 0000000002451410 0000000000000000): semi-stub
info: Setting display mode: 1920x1080@60
info: Setting display mode: 1920x1080@60
warn: DXGI: MakeWindowAssociation: Ignoring flags
```
I managed to fix it, by making a new distro and installing dxvk, d3d11, and dotnet via winetricks.